Since January 2020, when the genetic map of the Corona virus was first published, as a result of studies carried out all over the world, approximately 400 thousand whole genome sequences have been made on the virus and the data have been added to the National Center for Biotechnology Information database.
Dean of the Faculty of Medicine of Istanbul Medeniyet University (IMU) and Faculty Member of the Department of Physiology Prof. Dr. Sadrettin ClawHe said that with this 400 thousand genome sequencing, 12 thousand mutations have been detected in the virus so far, but a few of them are at a level that will affect the course or contagiousness of the disease.
Prof. Dr. “To make an explanation as to whether these mutations are effective or not, functional analysis is required. Many mutations have no effect on the course of the disease. These are very small scale mutations. Here, the effectiveness of increasing and increasing the severity and contagiousness of the disease becomes important. As of today, some of the new mutations have been found to increase contagiousness. As IMU, the D614 G mutation, which we found as a result of the whole genome study we did in the past months, was dominant all over the world. “Now the UK variant has come to the fore,” he said.
“ENGLAND, THE COUNTRY WITH THE HIGHEST SEQUENCE IN THE WORLD”
Stating that the UK variant has become dominant in 80 percent of the world as of today, Prof. Dr. “However, the South African mutation and the Brazilian mutation also came to the fore. England is the country with the most virus sequencing in the world. It follows this virus very closely. Therefore, there is a lot of data coming from England on this subject. Although it is declared that the UK variant increases the contagiousness but does not have any effect on the severity of the disease, there is an increase in deaths as the risk of getting sick increases as the rate of transmission increases. The South African variant contains both the mutation in England and the mutation in South Africa. This variant both increases contagiousness and increases disease severity. “There is a similar situation in the Brazilian variant,” he said.
“A DIFFERENT MUTATION MAY DEVELOPED IN EVERY REGION”
Pointing out that the most feared decrease in the effectiveness of vaccines in mutations, Prof. Dr. “For example, it was announced that a vaccine (Novavax) developed as a protein vaccine in the USA was 94 percent effective in the normal strain, while the effect decreased to 80 percent in the UK variant, and decreased to 50 percent in the South African variant,” said Claw. from Turkey of such whole genome studies also indicate that more needs to be done on the number of virus sequencing sneak Prof. Dr. Claw made the following warnings:
“I know that this issue has also been worked on. Next time we will also see their results from Turkey. Turkey in a country where a lot of input and output. Therefore, different mutations may develop in each region. They need to be determined and functional analyzes of these mutations should be made and ‘I wonder if they increase the infectiousness’ and ‘Does it affect the severity of the disease’ should be determined. Therefore, these studies, that is, the whole genome studies, need to be done frequently in many regions. There are many mutations in our country as well, but we do not have any data on how effective these are on the severity and contagiousness of the disease. We can say that the mutations so far have not changed this much. “
“FENCE GENERATION REGION SHOULD BE USED IN PCR TESTS”
Emphasizing that today’s virus is a very different virus from the day it first appeared, Prof. Dr. Claw concluded by saying that these changes may have effects on PCR tests that can diagnose the disease according to the virus gene regions:
“The virus, which has gone through 12 thousand mutations and reached the present day, is now in a very different situation. Of course, these mutations can also have an impact on PCR tests. Current PCR tests detect the virus through the N gene, S gene and orf1ab. These mutations are mostly on the N gene. It is absent in Orf1ab and very little in the S gene. Therefore, when you do PCR tests on at least two genes rather than one gene, the error rate is much lower. Of course, it is important to redesign PCR test primers according to new mutations. It is necessary to revise them and update the PCR tests. “
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